Pancreatic Cancer Can be early diagnosed

Aug 4, 2011 by Alexander

Although pancreatic cancer is not comparatively horrible as liver cancer  , the disease is still difficult to be early diagnosed and that is fearful. Research results show that the joint stool K-ras oncogene and tumor suppressor gene P53 mutation detection and tumor markers CA19-9 tests, early detection of pancreatic cancer may be. In the recently held directly under the Ministry of Health (tube) units of clinical examination and evaluation of key projects in the disciplines, the study of the judges, experts highly praised.
In recent years, the global incidence of pancreatic cancer are increasing every year. For many years there was no breakthrough in diagnostics and abroad. When the patient visits 3 / 4 is already late, five-year survival less than 5%. Such as investment in early diagnosis and treatment, five-year survival up to 20% to 50%. Therefore, the study of new screening and diagnostic tools to improve the early detection rate is the key to conquer pancreatic cancer.
The study found that duodenal cholangiopancreatography has the highest diagnostic sensitivity and accuracy; pancreatic cancer of a variety of oncogenes or tumor suppressor gene and protein abnormalities is very prominent. In the K-ras, P53, P16 gene abnormalities in two or more accounted for 18% to 47%, and chronic pancreatitis is no such phenomenon; through improved methods of DNA extraction from feces, get significantly higher than the expansion of foreign literature of the PCRincrease the success rate. On this basis, the combination of fecal K-ras mutations and P53 mutation, the sensitivity of diagnosis of pancreatic cancer up to 93.2%, If the above two tests of a kind of tumor marker CA19-9 combined test, the diagnosis of specific of up to 85% to 100%; confirmed by surgery and pathology of T1 (tumor confined to the pancreas, there is no lymph node metastases) in patients with pancreatic juice and stool K-ras mutation and P53 mutation rate than patients with T2 stage similar . The above study, they concluded that the joint stool K-ras, P53 mutation and CA19-9 tests, early detection of pancreatic cancer possible.
It is reported that the experts will carry out in the next step at high risk of pancreatic cancer (age older than 45 years, new diabetes, chronic pancreatitis, smoking, family history of cancer) in epidemiological investigations and follow-up to verify they introduced the screening method.
Tumor metastasis suppressor gene mutations in pancreatic cancer KAIL way has been found. Researchers thus believe that pancreatic cancer can be caused by gene mutations. The findings for people from the molecular level understanding of pancreatic cancer, invasion and metastasis development and provides the latest theory, but also to control and predict the cancer’s recurrence and metastasis provides the basis for clinical practice.
The transfer of cancer cells is a prominent feature of pancreatic cancer. According to statistics, only in the early stages, 80% of patients transferred, 40% of patients still in the lymph nodes and distant organs after transfer. In this regard, the medical profession has no significant effect of treatment strategies, the mortality rate of pancreatic cancer ranks fifth in all, and an upward trend.
KAIL genes and pancreatic cancer staging, degree of differentiation is closely related to, and devote themselves committed to the preparation of this gene and its expression in pancreatic cancer research, its future in-depth study of the gene transfer mechanism of inhibition of the foundation.
Transfer and non-metastatic tumor cells by comparison, as well as KAILDNA plasmid transfected pancreatic cancer cells and pancreatic cancer metastasis in nude mice model in vivo observation of adhesion molecules, cancer cells such as exercise and activity analysis revealed KAIL genes Early pancreatic cancer metastasis and anti-metastasis role in the process.
One study reported that smokers have the possibility of pancreatic cancer than non-smokers more than doubled. Smoking can make a person die from the disease or the likelihood of the disease reduced by 25%.
Brigham and Women’s Hospital and Harvard School of Public Health in Boston, researchers say, the United States pancreatic cancer and cancer-related deaths caused by the fifth leading cause 2.7 million deaths every year.
This of 16,800 men and women of 16 years of research shows that current smokers were more likely than non-smokers for pancreatic cancer is 2.5 times higher. The researchers say that a person smoking years longer, the more cigarettes smoked in, the greater the likelihood of pancreatic cancer.
The researchers said that in the surveyed people, quitting smoking in the first two years after the possibility of pancreatic cancer in a 48% drop. To quit smoking for 10 years, the possibility of pancreatic cancer follow the same non-smokers.